Hypersensitivity, triad (a combination of asthma, recurrent nasal polyposis, and paranasal sinuses and intolerance of and drugs pirazolonovogo series), hypovolemia (irrespective The cause), erosive and ulcerative lesions of the gastrointestinal tract in the acute stage , anticoagulation (including hemophilia), bleeding or a high risk of their development, severe renal insufficiency (plasma creatinine greater than 50 mg / l), liver failure, childbirth, lactation, children’s age (up to 16 years of age – safety and effectiveness not installed).
Hypersensitivity to other , asthma, winstrol the presence of factors that increase the toxicity to the gastrointestinal tract: alcoholism, smoking, and cholecystitis. postoperative period, chronic heart failure, edema syndrome, hypertension, renal dysfunction (plasma creatinine below 50 mg / l), cholestasis, active hepatitis, sepsis, systemic lupus erythematosus, simultaneous with others. , advanced age (over 65 years old ), pregnancy.
Use during pregnancy and lactation. Penetrates into breast milk in small quantities. Pregnancy and breast-feeding is contraindicated; in extreme situations should be weighed against the benefit to the mother and the risk to the fetus or child.
. Dosage and administration
. Intravenous, intramuscular and inwardly
When administered orally to patients 16 to 64 years old with a body weight above 50 kg, the recommended dose is 20 mg for the first reception, then – 10 mg four times a day but not more than . 40 mg / day
adult patients weighing less than 50 kg or with renal insufficiency – 10 mg in the first reception and further -. 10 mg four times a day
maximum daily dose for oral administration is 40 mg.
for parenteral administration to patients of 16 up to 64 years, more than 50 kg of body weight for one administration intramuscularly administered up to 60 mg (including oral dose); usually – 30 mg every 6 hours, not more than 3 times a day, I / – 30 mg (maximum of 15 doses of 5 days). Intramuscularly adult patients weighing less than 50 kg or with chronic renal failure for one administration is administered not more than 30 mg (including oral dose); . usually – 15 mg (20 doses over 5 days)
, more than 50 kg, 90 mg / day, maximum daily dose for intramuscular and intravenous administration are for patients 16 to 64 years old with a body weight; adult patients winstrol weighing less than 50 kg or with chronic renal insufficiency and elderly patients (65 years) – for intramuscular and intravenous administration of 60 mg. The duration of treatment should not exceed 5 days.
. Side effects
often – more than 3%, less frequently – 1-3%, rare – less than 1%. From the digestive system: often – gastralgia, diarrhea; less frequently – stomatitis, flatulence, constipation, vomiting, feeling of fullness; rare – loss of appetite, nausea, erosive and ulcerative lesions of the gastrointestinal tract (including perforation and / or bleeding – abdominal pain, spasm or a burning sensation in the epigastric region, blood in the stool or melena, vomiting blood or type “coffee grounds”, nausea, heartburn, etc.), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis.. From the urinary system: rarely – acute renal failure, back pain, hematuria, azotemia, hemolytic-uremic syndrome (hemolytic anemia , renal failure, thrombocytopenia, purpura), increased frequency of urination, increased or decreased amount of urine, nephritis, edema of renal origin. From the sensory organs: rarely – hearing loss, ringing in the ears, visual disturbances (including blurred visual perception) . The respiratory system: rarely – bronchospasm or dyspnea, rhinitis, pulmonary edema, laryngeal edema (shortness of breath, difficulty breathing). On the part of the central nervous system: often – headache, dizziness, drowsiness, rarely – aseptic meningitis (fever, severe headache pain, cramps, stiffness in the neck muscles and / or back), hyperactivity (mood changes, anxiety), hallucinations, depression, psychosis, fainting. cardio-vascular system: less winstrol often – increased blood pressure. From the side of hematopoiesis: rarely – anemia, eosinophilia, leukopenia. On the part of the hemostatic system: rarely – bleeding from surgical wounds, nosebleeds, rectal bleeding.For the skin: less often – skin rash (including makulopapulleznuyu rash), purpura, rarely – exfoliative dermatitis (fever with chills or without redness, induration or peeling of the skin, swelling and / or tenderness of the tonsils), urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome). Local reactions: less often – a burning sensation or pain in the site of injection. Allergic reactions: rare – anaphylaxis or anaphylactoid reactions (change in skin color, skin rash, hives, itchy skin, tachypnea or dyspnea, edema of the eyelids, periorbital edema, shortness of breath, difficulty breathing, heaviness in the chest, wheezing). Other: often – edema (face, legs, ankles, fingers, feet, weight gain); less often – sweating, rarely – swelling of the tongue, fever.