Vomiting and nausea of various origins (including on the background of functional and organic diseases, infections, and toxemia, radiation therapy, diet violations, drug genesis – receiving morphine, apomorphine, levodopa and bromocriptine; during endoscopic and X-ray contrast studies GI), hiccup, atonic gastrointestinal tract (including post-operative); the need to accelerate winstrol for women peristalsis during radiopaque GI research.
dyspeptic disorders on the background of delayed gastric emptying, gastroesophageal reflux and esophagitis: a feeling of fullness in the epigastrium, feeling of bloating, flatulence, gastralgia, heartburn, regurgitation with or without reflux of gastric contents into the casting mouth.
Hypersensitivity, bleeding from the gastrointestinal tract, mechanical intestinal obstruction, perforation of the stomach or intestines, prolactinoma, lactation, children’s age (up to 5 years of age and for children weighing up to 20 kg).
during pregnancy, renal and / or hepatic insufficiency.
Use during pregnancy and lactation
on the use of data during pregnancy is not enough. To date there is no evidence of an increased risk of malformations in humans. However assign during pregnancy should only if its use is justified for the expected therapeutic benefit of the mother and minimum risk to the fetus.
Women concentration in breast milk is from 10 to 50% of the corresponding plasma concentrations and less than 10 ng / ml. The total amount of excreted in breast milk – less than 7 micrograms per day in the application of the maximum permissible dose of . It is unknown whether this concentration has a negative impact on infants. In this regard, the application of during lactation should stop breastfeeding.
Dosing and Administration
Inside for 15-20 minutes before eating. Adults and children over 5 years with chronic dyspeptic phenomena – 10 mg 3-4 times a day, including before going to bed, if necessary.
In severe nausea and vomiting – 20 mg 3-4 times a day, before the last reception bedtime. The maximum daily dose – 80 mg.
For patients with renal failure dose adjustment is necessary, frequency of intake should not exceed 1 to 2 times during the day.
Side effect From the digestive system: Gastrointestinal disorders (transient intestinal cramps). From the nervous system: extrapyramidal winstrol for women disorder (in children and patients with increased permeability of the BBB, in adults – single cases); these effects are completely reversible and disappear after discontinuation of the drug. Allergic reactions: skin rash, urticaria. Other: hyperprolactinemia (galactorrhea, gynecomastia, amenorrhea).
Overdosing Symptoms: drowsiness, disorientation, extrapyramidal disorder (especially in children). Treatment: reception activated carbon, with extrapyramidal disorders – m-holinoblokatory, antiparkinsonian drugs or antihistamines with anticholinergic properties.
Interaction with other drugs
cimetidine, sodium bicarbonate reduces the bioavailability of . M-holinoblokatory and antacid drugs neutralize the action of .
Increasing the concentration of plasma inhibitors of CYP3A4 isoenzyme: antifungal drugs azole, macrolide antibiotics, HIV protease inhibitors, nefazodone (an antidepressant). When co-administered with ketoconazole achieved approximately three-fold increase in the maximum concentration of .
Simultaneous treatment with paracetamol and digoxin had no effect on the concentration of these drugs in the blood.
Compatible with antipsychotic drugs (neuroleptics) and dopaminergic receptors agonists (bromocriptine, levodopa).
When combined with taking antacids winstrol for women or agents that reduce gastric acid secretion, the latter should be taken after meals and not before meals, ie should not be taken simultaneously with .
Effects on ability to drive and operate machinery
does not affect the ability to drive vehicles and other classes of potentially hazardous activities that require high concentration and psychomotor speed reactions.
Tablets film-coated 10 mg.
10 tablets in blisters of PVC film and aluminum foil printed patent.
1, 2, 3, 4 or 5 contour cell packages with instruction in a pile of cardboard.
In a dry, dark place at a temperature no higher than 25 ° C. Keep out of the reach of children.