Hypersensitivity, gastrointestinal bleeding, mechanical obstruction, perforation of the stomach or intestines, prolactin-secreting pituitary tumor (prolactinoma), children up to 5 years.
When administered to animals at doses up to 160 mg / kg / day domperidone okazyvapg not teratogenic. However, like most medications, Dometal should be administered during the I trimester of pregnancy only if its use is justified by the expected therapeutic benefit. To date there is no evidence of an increased risk buy winstrol of malformations in humans. Women domperidone concentrations in breast milk is 4 times lower than corresponding concentrations in plasma. It is unknown whether this level has a negative effect on infants. Therefore, if the mother takes Dometal, breast-feeding is not recommended.
Dosing and Administration
1. Chronic dyspepsia Adults: 10 mg (1 tablet) 3 times a day 15-30 minutes before meals and, if necessary, before bedtime. Children older than 5 years: 2.5 mg per 10 kg body weight. 3 times a day before meals and, if necessary, before bedtime. Specified dosage can be doubled if necessary.
2. Acute and subacute states (mainly nausea and vomiting) Adults: 20 mg (2 tablets) 3-4 times a day before meals and at bedtime. Children over 5 years: 5 mg per 10 kg body weight, 3- 4 times a day before meals and at bedtime. Notes. Recommended reducing the frequency of drug administration (see. “Special Instructions” section) In renal insufficiency.
From the digestive system: transient intestinal cramps. From the nervous system: extrapyramidal disorder (for children and persons with increased permeability of the blood-brain barrier). Allergic buy winstrol reactions: skin rash, urticaria. Other: hyperprolactinemia (galactorrhea, gynecomastia).
Symptoms: drowsiness, disorientation and extrapyramidal reactions (especially in children). Treatment: administration of activated charcoal, in the event of extrapyramidal reactions – anticholinergic, antiparkinsonian, antihistamines.
Interaction with other medicinal products .
Cimetidine, sodium bicarbonate, and other antacid protivosekretornye drugs reduce the bioavailability of Domperidone.
Anticholinergic agents neutralize the action of domperidone.
Increasing the concentration of domperidone in plasma: antifungal azole agents, macrolide antibiotics, HIV protease inhibitors, nefazodone.
In patients with severe renal impairment (serum creatinine> 6 mg / 100 ml, ie> 0.6 mmol / L) increased the half-life of domperidone from 7.4 to 20.8 hours, but the concentration of the drug in the plasma were lower than healthy volunteers. Since a very small percentage of the drug is excreted by the kidneys in an unmodified form, it is hardly necessary correction of a single dose in patients with renal insufficiency.However, with repeated administration frequency assignment must be reduced to 1-2 times a day, depending on the disease severity. It may also be necessary to dose reduction. When long-term therapy patients should buy winstrol be regularly monitored.
10 mg tablets. 10 tablets in blister packs of aluminum foil and PVC film.
1 or 3 blisters with instruction on use in carton box.
4 tablets in a blister made of PVC film and aluminum foil. 1 blister with instructions for use in a cardboard box (sample not for sale)
4 years. Do not use after the expiration date printed on the packaging.
At temperatures below 30 ° C protected from light, out of reach of children.